Nam Co is the largest (1920 km2 in area) and highest (4718 m above sea level) lake in Tibet. According to the discovery of lake terraces and highstand lacustrine deposits at several places in Nam Co and its adjacent areas, the authors confirm the existence of an ancient large lake in the southeastern part of the northern Tibetan Plateau. On the basis of the U-series, 14C and ESR dating, coupled with the levelling survey of lake deposits and geomorphology, the evolutionary process of the ancient large lake in the southeastern part of the northern Tibetan Plateau may fall into three stages: (1) the ancient large lake stage at 115-40 ka BP, when the ancient lake level was 140-26 m above the level of present Nam Co; (2) the outflow lake stage at 40-30 ka BP, when the ancient level was 26-19 m above the present lake level; and (3) the Nam Co stage since 30 ka BP, when the ancient lake level was < 19 m above the present lake level. During the ancient large lake stage, a large number of modern large, medium-sized and small lakes, including Nam Co, Siling Co and Zhari Namco, in the southeastern part of the northern Tibetan Plateau, were connected into a single large ancient lake, rather than several separate lakes connected by river channels. Its areal extent may have gone beyond the watersheds of the modern endorheic and exorheic drainage systems; so it may be called the "ancient east lake", "ancient south lake" and "ancient west lake". It might also be connected with other ancient lakes in the southern and western parts of the northern Tibetan Plateau to form a unified "ancient large lake" on the northern Tibetan Plateau.