Fethiye is an important region located in the eastern part of the Mediterranean Basin. This region which is the most active part of the south-western Anatolia extensional tectonic regime, has been effected by earthquakes, submarine landslides and tsunamis throughout the history due to the existence of the complex active plate boundary zone. The active area has been exposed to ground motion that had the potential to damage vulnerable structures. Therefore, a detailed assessment of seismic hazard is necessary for the prevention of potential damage. In this context, probabilistic seismic hazard analysis is performed by R-CRISIS-18.3 using the refined parameters computed from Seismic Hazard Harmonization for Europe (SHARE) project. Spatial distribution of spectral acceleration at T = 0.2 s and T = 1.0 s for the earthquake levels that corresponds to the average return period of 72, 475 and 2475 years is calculated. Hazard curves for the central region of Fethiye district are generated. The results are discussed and compared with the values obtained from the Revision of Turkish Seismic Hazard Map Project (UDAP-?-13-06). These local results of probabilistic seismic hazard analysis will provide the basis for the preparation of seismic risk maps as future work.