Research on the distribution of mantle CO2 should involve comprehensive analysis from CO2 source to accumulation. The crust-mantle pathway system is the key controlling factor of the distribution of mantle CO2, but has received little attention. The pathway system and controlling factors of CO2 distribution in the Bohai Sea are analyzed using data on fault styles and information on the mantle and lithosphere. The relation between volcanic rocks and the distribution of mantle CO2 is reassessed using age data for CO2 accumulations. The distribution of mantle CO2 is controlled by uplift of the asthenosphere and upper mantle, magma conduits in the mantle and fault systems in the crust. Uplifted regions of the asthenosphere are accumulation areas for CO2. The area with uplift of the Moho exhibits accumulation of mantle CO2 at depth. CO2 was mainly derived from vertical migration through the upper mantle and lower crust. The fault style in the upper crust controls the distance of horizontal migration and the locations of CO2 concentrations. The distribution of mantle CO2 and volcanic rocks are not the same, but both probably followed the same pathways sometimes. Mantle CO2 in the Bohai Sea is concentrated in the Bozhong sag and the surrounding area, particularly in a trap that formed before 5.1 Ma and is connected to crustal faults (the Bozhang faults) and lithospheric faults (the Tanlu faults).