Abstract: Recent rapid progress in cyberinfrastructure in geosciences is providing seismologists an enormous boost for addressing multi-physical phenomena of regional seismic activities. The inherent nature of their multi-scale properties, from temporal to spatial spaces, makes it inevitably to be solved using large-scale computations and distributed parallel data processing schemes. Under such circumstance, using the advanced numerical algorithms and unstructured mesh generation technologies become the obstacles for modern seismologists. The main objective of this paper is to present a framework, which includes a parallel finite element simulation and distributed data infrastructure, to address the novel algorithms, state-of-the-art modeling and their implementation in regional seismicgenic systems. We also discuss and implement this framework to analyze the strong earthquake evolution processes in the Sichuan-Yunnan region. This study is the key to long-term seismic risk by estimates, providing a platform for predictive large-scale numerical simulation modeling of regional earthquake activities.