Rubidium (Rb) deposits mostly occur in the South China and Central Asia orogenic belts and are often closely associated with highly differentiated granites. This study investigates a newly-discovered giant Rb deposit at Gariatong in the Central Lhasa terrane in Tibet. Detailed field studies and logging data revealed that the Rb mineralization mainly occurs in monzogranite and is related to greisenization. LA-ICP-MS U-Pb dating of zircon yielded ages of 19.1 ± 0.2 Ma and 19.0 ± 0.2 Ma for greisenized monzogranite and fresh monzogranite, respectively. The monzogranites are characterized as strongly peraluminous, with high contents of SiO2, Al2O3, K2O and Na2O as well as a high differentiation index. They are enriched in light rare earth and large ion lithophile elements with signi?cant negative Eu anomalies and depleted high field-strength elements. Petrological and geochemical features of these ore-related monzogranites suggest that they are highly fractionated S-type granites, derived from remelting of crustal materials in a post-collisional setting. The geochemistry of zircon and apatite points to a low oxygen fugacity of the ore-related monzogranite during the magma’s evolution. The discovery of the Gariatong Rb deposit suggests that the Central Lhasa terrane may be an important region for rare metal mineralization.