South China is the most important polymetallic (tungsten, tin, bismuth, copper, silver, antimony, mercury, rare metals, heavy rare earth elements, gold and lead-zinc) province in China. This paper describes the basic characteristics of Mesozoic large-scale mineralization in South China. The large-scale mineralization mainly took place in three intervals: 170-150 Ma, 140-126 Ma and 110-80 Ma. Among these the first stage is mainly marked by copper, lead-zinc and tungsten mineralization and the third stage is mainly characterized by tin, gold, silver and uranium mineralization. The stage of 140-126 Ma mainly characterized by tungsten and tin mineralization is a transitional interval from the first to the third stage. In light of the current research results of the regional tectonic evolution it is proposed that the large-scale mineralization in the three stages is related to post-collision between the South China block and the North China block, transfer of the principal stress-field of tectonic regimes from N-S to E-W direction, and multiple back-arc lithospheric extensions caused by subduction of the Paleo-Pacific plate.