The fold-thrust belt foreland basin system is generally controlled by the process of shallow tectonic denudation-sedimentation and its related coupling mechanism, so it has complex three-dimensional tectonic deformation characteristics and evolution process. Under the remote effect of plate collision, out-of-sequence structures were formed in Xuefeng intracontinental fold and thrust belt in Upside Yangtze region. Based on the structural analysis of deep and large fault zones in the study area, fault calcite U-Pb chronology and deep structural interpretation of seismic profiles, the deformation process of Xuefeng intracontinental fold and thrust belt is reviewed: (1) In the Late Triassic to Early Jurassic (200Ma), the intracontinental fold thrust deformation occurred initially, and the Cili-Baojing fault began to move; (2) In the Late Jurassic and Early Cretaceous (120-160Ma), the multi-layer system slip caused the thrust deformation to extend to the Hubei, Chongqing, Hunan and Guizhou regions, and Jianshi-Pengshui fault began to move. (3) In the Late Cretaceous-Early Palaeo-Modern period (71-52Ma), the Enshi-Youyang and Hefeng-Laifeng faults began to move, and further extrusion folding and thrust-deformation occurred. The fault chronology and the deformation stress field in the study area jointly reveal the process of the Xuefeng intracontinental thrust system showing overthrust deformation before the Indochinese period and the back-camel structure deformation during the Yanshan period, which together form the structural characteristics of the foreland thrust belt with low wedge top Angle and wide deformation area in the Yangtze landmass, and control the formation and evolution of the ancient Yangtze continental lake basin in the Upper Yangtze region.