The formation of mineral deposits is related to a particular stage of the Earth' evolution and controlled by a specific geological environment, the deep structure and geodynamic process play a major role in controlling mineralization. The present crustal structure of metallogenic belt or oreconcentrated area retains "fossil" marks preserved during its geodynamic evolution. Through the detection of crustal structure at different depths, we can not only reveal the tectonic setting and metallogenic environment at the time of the mineral system (fluid source, migration pathway and trap) was formed, but also can directly trace the extension of the deeper orecontrolling structures, and even directly detect the deeper ore bodies. Reflection seismic is a key technology for deep structure detection, and has been used for continental crust structure study and oil and gas exploration for about a hundred years, however, the application of this technique in research of metallogenesis and deep mineral exploration in hard rock environments is only about two decades. This paper reviews the recent advances of reflection seismic in studding of regional metallogenic background, 3D structures of the oreconcentration area and deep mineral exploration, and discusses the problems and the future development, and hope to provide some reference to SinoProbe project, which will carry out threedimensional detection in key metallogenic belt and ore concentration area in China.