The magmatic hydrothermal polymetallic metallogenic belt in the northeastern part of the Gangdese polymetallic belt formed in the initial stages of Indian- Asian collision. This belt contains various types of deposits with different metal associations. Previous studies were mainly focused on the Pb- Zn, Mo and Fe- Cu metallogenic systems, leading to limited understanding of the Cu metallogenic system. The Chengbabu deposit, which located in the south of the northeastern Gangdese metallogenic belt, is the only skarn deposit dominated by Cu mineralization. Thus, it provides a good opportunity to study the metallogenesis and regional exploration potential of Cu in the belt. The ore bodies in Chengbapu mainly occur in skarns that are interbedded between the Lower Cretaceous Linbuzong Formation slate and the Upper Jurassic Duodigou Formation limestone. Ore minerals (chalcopyrite, sphalerite and molybdenite) mainly occur in the quartz sulfide stage. The Re- Os isotope of molybdenite from skarn gives an isochron age of 59.0±0.8 Ma. LA- ICP- MS zircon U- Pb dating of diorite and granodiorite porphyry associated with the mineralization are 58.9±0.9 Ma and 58.7±0.8 Ma, respectively. These data indicate that the Chengbapu deposit was formed in the main India- Asia collision, which are similar to the ages of other deposits in the northeastern Gangdese polymetallic metallogenic belt. The diorite and granodiorite porphyry, identified as I- type granites, are genetically related. Granodiorite porphyries are derived from diorite by fractional crystallization of amphibole and plagioclase. For diorite and granodiorite porphyry, zircon εHf(t) values range from +0.3 to +7.6, and εNd(t) values range from 0.1 to +0.5. It indicates juvenile lower continental crust source region which has been reworked by mantle- derived material. Zircon εHf(t) contour map of the northern Gangdese polymetallic metallogenic belt indicates that the mineralization is controlled by crustal structure and magma source. It also suggests that the Pb- Zn deposits were mainly developed in the area where have ancient crustal sources. The transition region of the juvenile and ancient crustal sources, and south of Chengbapu deposit have potential to find large- medium Cu deposits.