Ningwu basin, one of the most important mineral districts in the Middle and Lower reaches of the Yangtze River metallogenic belt, is characterized by the extensive development of Mesozoic volcanic rocks as well as iron ore deposits. With increasing of deep prospect in this area in recent years, finding ore deposits is increasingly difficult accompanied by increasing cost. It is high time to use geophysical methods to resolve deep geological structure, provide direct information for deep prospecting and reducing exploration risk. In order to understand the spatial distribution of deep structure, rocks and strata in the Zhonggu ore field in the south section of Ningwu Basin, this study carried out the inversion rese arch of deep geological structure and determined the distribution of strata and rocks through the regional gravitymagnetic data and and drilling geological information. Based on the combination modes of gravity- magnetic prospecting and geological factors of ore controlling, two favorable prospecting targets in the Zhonggu ore field have been determined through inversion results. And this will provide references for the next step of prospecting.