The Huangshaping polymetallic deposit is the largest lead-zinc mine in southern Hunan Province. The biggest granite occurred in mining area occupies only 0.6 km2, however, the small size granitoids in Huangshaping area have led to the accumulation of huge amounts of metals. The sources of ore-forming materials are critical to understand the ore genesis. To clarify the source of sulfur in Huangshaping deposit, we systematically studied the sulfur isotope composition of quartz porphyry and granite porphyry samples collected from the different locations of mining area. The result shows that δ34S values of quartz porphyry and granite porphyry range from + 4.1‰ to + 7.5‰, and from 4.9‰ to + 11.4‰, respectively. The analysis of these data suggest that the range of magmaδ34S values, which is probably slightly below the range of granitoids δ34S values (+4.1‰ to + 11.4‰), is well consistent with the sulfur isotope values of typical S-type granites. Combined with the previous sulfidesδ34S data, it is indicated that the sulfur of sulfides with high δ34S values was partly originated from the carbonate strata besides the magmatic sulfur. Maybe, this is one of the most important reasons that the largest lead-zinc mine in southern Hunan Province developed in the Huangshaping mining area.