On the basics of geological surveys and researches indoor, the article introduces C, Si,O,S and Pb isotope characteristics of Caima skarn-type iron deposit, Fuye skarn-type iron deposit, Garqiong skarn-type copper-gold deposit and Duobuza porphyry-type copper-gold deposit of Bangonghu-Nujiang metallogenic belt. The results of δ30Si-δ18O research suggest that quartzes are mainly magma hydrothermal genesis; the results of δ18O-δ13C isotope suggest that C related with mineralization of skarn, magnetite marble is mainly from mantle, except some of that comes from the solution of marine carbonate. Most of Pb isotopes of the samples from Duobuza and Garqiong mine fields locate the evolution lines of orogene, and are richer than those of Gangdis metallogenic belt. That is the result of mixing of mantle Pb and lower crust Pb. The tectonic background is orogene, and some is close to lower crust. The Pb isotope composition ranges in the orogenic area, belongs to Pb of crust source. For the reason that, the Pb of Garqiong and Duobuza mine fields derive from the course of orogeny and the stage of arc-continent collision in Bangonghu-Nujiang metallogenic belt. This article summarizes the regional genetic model in the west section of Bangonghu-Nujiang metallogenic betlt. That is Cretaceous mid-acid magma invade Permian, Trias and Cretaceous marine carbonate, then skarn ore bodies form in external contact zones, and if it invades mid-Jurassic and lower Cretaceous sandstone and siltstone, porphyry-type ore bodied form in internal and external contact zones.