Vertical differential structural deformation (VDSD), one of the most significant structural characteristics of strike-slip fault zones (SSFZs) in the Shunbei area, is crucial for understanding deformation in the SSFZ and its hydrocarbon accumulation significance. Based on drilling data and high-precision 3-D seismic data, we analyzed the geometric and kinematic characteristics of the SSFZs in the Shunbei area. Coupled with the stratification of the rock mechanism, the structural deformations of these SSFZs in different formations were differentiated and divided into four deformation layers. According to comprehensive structural interpretations and comparisons, three integrated 3-D structural models could describe the VDSD of these SSFZs. The time-space coupling of the material basis (rock mechanism stratification), changing dynamic conditions (e.g., changing stress-strain states), and special deformation mechanism of the en echelon normal fault array uniformly controlled the formation of the VDSD in the SSFZs of the Shunbei area. The VDSD of the SSFZs in this area controlled the entire hydrocarbon accumulation process. Multi-stage structural superimposing deformation influenced the hydrocarbon migration, accumulation, distribution, preservation, and secondary adjustments.