The Egyptian older and younger granitic rocks emplaced during pre- and post-collision stages of Neoproterozoic Pan-African orogeny, respectively, are widely distributed in the southern Sinai Peninsula, constituting 70% of the basement outcrops. The Wadi El-Akhder, southwestern Sinai, is a mountainous terrain exposing two granitoid suites, namely the Wadi El-Akhder Older Granites (AOG) and the Homra Younger Granites (HYG). The AOG (granodiorites with subordinate tonalite compositions) have geochemical characteristics of medium-K calc-alkaline, metaluminous to mildly peraluminous granitoids formed in an island-arc environment, which are conformable with well-known Egyptian older granitoids rocks, whereas the HYG display calc-alkaline to slightly alkaline nature, peraluminous syeno-, monzogranites and alkali feldspar granites matching well those of the Egyptian younger granites. With respect to the AOG granitoids, the HYG granites contain lower Al2O3, FeO*, MgO, MnO, CaO, TiO2, Sr, Ba, and V, but higher Na2O, K2O, Nb, Zr, Th, and Rb. The AOG are generally characterized by enrichment in LILE and LREE and depletion in HFSE relative to N-MORB values (e.g., negative Nb and Ta anomalies). The geochemical features of the AOG follow assimilation-fractional crystallization (AFC) trends indicative of extensive crustal contamination of magma derived from a mantle source. The chemical characteristics of the AOG are remarkably similar to those of subduction-related granitoids from the Arabian-Nubian Shield (ANS). The compositional variations from monzogranites through syenogranites to alkali feldspar granite within HYG could not be explained by fractional crystallization solely. Correlating the whole-rock composition of the HYG to melts generated by experimental dehydration melting of meta-sedimentary and magmatic rocks reveals that they appear to be derived by extended melting of psammitic and pelitic metasediments, which is similar to the most of younger granitic suites in the ANS.