The Pamir Plateau can be divided into three secondary tectonic units from north to south: the North, the Middle and the South Pamir Blocks. The North Pamir Block belonged to the southern margin of Tarim-Karakum, thermochronological study of the Pamir structural intersection indicates that accretion of the Middle Pamir Block to the Eurasian Continental Margin and its subduction and collision with the North Pamir Block occurred in the Middle–Late Jurassic. Due to the Neo-Tethys closure in the Early Cretaceous, the South Pamir Block began to collide with the accretion (the Middle Pamir Block) of the Eurasian Continental Margin. Affected by the collision and continuous convergence between the Indian Plate and the Eurasian Plate since the Cenozoic, Pamir is in a multi-stage differential uplift process. During 56.1–48.5 Ma, North Pamir took the lead in uplifting, that is, the first rapid uplift in the Pamir region began there. The continuous compression and contraction of the Indian and Eurasian plates during 22.0–15.1 Ma forced the Pamir tectonic syntaxis to begin its overall uplift, i.e. Pamir began to enter the second rapid uplift stage in the Early Oligocene, which lasted until the Middle Miocene. During 14.6–8.5Ma, South Pamir was in a rapid uplift stage, while North Pamir was in a relatively stable state, showing asymmetry of tectonic deformation in the Pamir region in space. Since 6.5 Ma, Pamir began to rapidly uplift again.