The Jiangda–Deqen–Weixi continental margin arc (DWCA) developed along the base of the Changdu–Simao Block and was formed as a result of the subduction of the Jinsha River Ocean Slab and the subsequent collision. The Ludian batholith is located in the southern part of the DWCA and is the largest batholith in northwest Yunnan. Granite samples from the Ludian batholith yield an early Middle Permian age of 271.0 ± 2.8 Ma. The geochemical data of the early Middle Permian granitoids show high Si2O, low P2O5 and MgO contents that belong to calc-alkaline series and peraluminous I-type rocks. Their εHf(t) values range from ?5.01 to +0.58, indicating that they were formed by hybrid magmas related to the subduction of the Jinsha River Tethys Ocean. The monzonite and monzogranite samples yield Late Permian ages of 250.6 ± 1.8 Ma and 252.1 ± 1.3 Ma, respectively. The Late Permian granitoids are high-K calc alkaline and shoshonite series metaluminous I-type rocks. Their εHf(t) values range from ?4.12 to ?1.68 and from ?7.88 to ?6.64, respectively. The mixing of crustal and mantle melts formed the parental magma of the Late Permian granitoids. This study, combined with previous work, demonstrates the process from subduction to collision of the Jinsha River Paleo-Tethys Ocean.