The South Qilian belt mainly comprises an early Paleozoic arc-ophiolite complex, accretionary prism, micro-continental block, and foreland basin. These elements represent accretion-collision during Cambrian to Silurian time in response to closure of the Proto-Tethyan Ocean in the NE of the present-day Tibet Plateau. Closure of the Proto-Tethyan Ocean between the Central Qilian block and the Oulongbuluke block and the associated collision took place from NE to SW in a zipper-like style. Sediment would have been dispersed longitudinally SW-ward with a progressive facies migration from marginal alluvial sediments toward slope deep-water and deep-sea turbidites. This migration path indicates an ocean basin that shrank toward the SW. The Balonggongga’er Formation in the western South Qilian belt represents the fill of a latest Ordovician-Silurian remnant ocean basin that separated the Oulongbuluke block from the Central Qilian block, and records Silurian closure of the Proto-Tethyan Ocean and subduction beneath the Central Qilian block. However, alluvial deposits in the Lajishan area were accumulated in a retro-foreland basin, indicating that continent-continent collision in the eastern South Qilian belt occurred at c. 450–440 Ma. These results demonstrate that the Proto-Tethyan Ocean closed diachronously during early Paleozoic time.