A great number of magmatic Cu-Ni deposits (including Kalatongke in Xinjiang and Hongqiling in Jilin) are distributed over a distance of almost 3000 km across the Tianshan-Xingmeng Orogenic Belt, from Tianshan Mountains in Xinjiang in the west, to Jilin in eastern China in the east. These deposits were formed during a range of magmatic episodes from the Devonian to the Triassic. Significant magmatic Cu-Ni-Co-PGE deposits were formed from the Devonian period in the Nalati arc (e.g. Jingbulake Cu-Ni in Xinjiang), Carboniferous period in the Puerjin-Ertai arc (e.g. Kalatongke Cu-Ni-Co-PGE in Xinjiang), Carboniferous period in the Dananhu-Touquan arc (e.g. Huangshandong, Xiangshan and Tulaergen in estern Tianshan, Xinjiang) to Triassic period in the Hulan arc (e.g. Hongqiling Cu-Ni in Jilin). In addition to the overall tectonic, geologic and distribution of magmatic Cu-Ni deposits in the Tianshan-Xingmeng Orogenic Belt, the metallogenic setting, deposit geology and mineralization characteristics of each deposit mentioned above are summarized in this paper. Geochronologic data of Cu-Ni deposits indicate that, from west to east, the metallogenic ages in the Tianshan-Xingmeng Orogenic Belt changed with time, namely, from the Late Caledonian (~440 Ma), through the Late Hercynian (300–265 Ma) to the Late Indosinian (225–200 Ma). Such variation could reflect a gradual scissor type closure of the paleo Asian ocean between the Siberia Craton and the North China Craton from west to east.