Downhole microseismic data has the significant advantages of high signal-to-noise ratio and well-developed P and S waves and the core component of microseismic monitoring is microseismic event location associated with hydraulic fracturing in a relatively high confidence level and accuracy. In this study, we present a multidimensional DIRECT inversion method for microseismic locations and applicability tests over modeling data based on a downhole microseismic monitoring system. Synthetic tests inidcate that the objective function of locations can be defined as a multi-dimensional matrix space by employing the global optimization DIRECT algorithm, because it can be run without the initial value and objective function derivation, and the discretely scattered objective points lead to an expeditious contraction of objective functions in each dimension. This study shows that the DIRECT algorithm can be extensively applied in real downhole microseismic monitoring data from hydraulic fracturing completions. Therefore, the methodology, based on a multidimensional DIRECT algorithm, can provide significant high accuracy and convergent efficiency as well as robust computation for interpretable spatiotemporal microseismic evolution, which is more suitable for real-time processing of a large amount of downhole microseismic monitoring data.