The 300±20 Ma anomalously radioactive trachytes of Wadi El Kareim, central Eastern Desert, are a significant example of U-mineralization related to the alkaline volcanics in Egypt. Extensive portable gamma-ray spectrometric data has been utilized to identify geological factors controlling uranium mobility in the geological units along the three detailed study locations of Kab Al-Abyad, South Wadi (W) Al-Tarafawy and W. Al-Farkhah; their eTh/eU ratios averaging around 4.1, 3.7 and 5.6 respectively. Quantitative analysis with the integration of mobility maps and geological studies suggest two systems controlling U-migration within the geological units (confined system and unconfined system). In the confined system, the syngenetically formed U have experienced mobility after leaching and are redistributed in the presence of an incorporation carrier during transportation (probably as carbonate complexes). Then the retardant for uranium is achieved by sorption or by coprecipitation with the aid of Fe oxy-hydroxide, and finally the formation of immobile secondary U-bearing minerals takes place along a lithogeochemical trap. In contrast to the confined system, the unconfined one is basically lacking the lithogeochemical trap which in?uences the final accumulation of U-bearing minerals. The radioactivity of the trachyte rocks arises from the radioactive minerals uranophane and beta-uranophane with U- and/or Th-bearing minerals samarskite, Th-rich REE silicates, monazite and allanite.