The South Altyn continental block is an important geological unit of the Altyn Tagh orogenic belt, in which numerous Neoproterozoic granitoids crop out. Granitoids are mainly located in the Paxialayidang–Yaganbuyang area and can provide indispensable information on the dynamics of Rodinia supercontinent aggregation during the Neoproterozoic. Therefore, the study of granitoids can help us understand the formation and evolutionary history of the Altyn Tagh orogenic belt. In this work, we investigated the Yaganbuyang granitic pluton through petrography, geochemistry, zircon U–Pb chronology, and Hf isotope approaches. We obtained the following conclusions: (1) Yaganbuyang granitoids mainly consist of two-mica granite and granodiorite. Geochemical data suggested that these granitoids are peraluminous calc–alkaline or high-K calc–alkaline granite types. Zircon U–Pb data yielded ages of 939±7.1 Ma for granodiorite and ~954 Ma for granitoids, respectively. (2) The εHf(t) values of two–mica granite and granodiorite are in the range of ?3.93 to +5.30 and ?8.64 to +5.19, respectively. The Hf model ages (TDM2) of two-mica granite and granodiorite range from 1.59–.05 Ga and 1.62–2.35 Ga, respectively, indicating that the parental magma of these materials is derived from ancient crust with a portion of juvenile crust. (3) Granitoids formed in a collisional orogen setting, which may be a response to Rodinia supercontinent convergence during the Neoproterozoic.