The newly discovered Paodaoling porphyry Au deposit from the Guichi region, Lower Yangtze River Metallogenic Belt (LYRB), contains >35 tons of Au at an average grade of ~1.7 g/t. It is a porphyry ‘Au-only’ deposit, as revealed by current exploration in the depths, mostly above ?400 m, which is quite uncommon among coeval porphyry mineralization along the LYRB. Additionally, there are also Cu-Au bearing porphyries and barren alkaline granitoids in the Paodaoling district. Zircon LA-ICP-MS U-Pb dating of the Cu-Au-bearing porphyries yield an age of 141–140 Ma, falling within the main magmatic stage of the LYRB, whereas the barren granites give an age of 125–120 Ma, coeval with the regional A-type granites. The Cu-Au-bearing porphyries are LILE-, LREE-enriched and HFSE-depleted, typical of arc magmatic affinities. The barren granites are HFSE-enriched, with lower LREE/HREE ratios and pronounced negative Eu anomalies. The Cu-Au-bearing porphyries in the Paodaoling district have high oxygen fugacities and high water content. Pyrite sulfur isotopes of the Paodaoling gold deposit indicate a magmatic-sedimentary mixed source for the ore-forming fluids. Based on the alteration and poly-metal zonation of the deepest exploration drill hole from the Paodaoling Au deposit, we propose that Cu ore bodies could lie at depth beneath the current Au ore bodies. The magmatism and associated Cu-Au mineralization of the Paodaoling district are likely to have formed in a subduction setting, during slab rollback of the paleo-Pacific plate.