The crystal structure of lisiguangite, CuPtBiS3, from Yanshan mountains, Chengde Prefecture, Hebei Province, China has been determined by single crystal X-ray diffraction. It belongs to orthorhombic space group P212121 with a = 7.7372(15) ?, b = 12.844(3) ?, c = 4.9062(10) ?, V = 487.57(17) ?3, Z = 4. The final full-matric least-square refinement on F2 converged with R1 = 0.0495 and wR2 = 0.0992 for 704 observed reflections [I≥2σ(I)]. Lisiguangite is the isomorph of known CuNiSbS3 and CuNiBiS3. Pt2+ and Bi3+ have the distorted octahedral coordination enviroments composed of two metal and four S and Cu+2 has a distorted tetrahedral coordination environment with four S atoms. Each S atom is surrounded by four metals to give a tetrahedral environment. The crystal structure is a complex 3 dimensional network.