The basin-mountain system in the Sichuan Basin (SCB) reflects the main tectonic activity and the orogenic denudation in this region. The seismic probing work reveals the deep structure of the basin-mountain system. The seismic work was re-sampled to the Moho depth and the sedimentary thickness as well as the P-wave velocity-depth function to analyze the deep structure of the SCB and adjacent orogens. The results show two deposit centers in the SCB: the Deyang area in the west and the Nanchuan area in the east and depression uplift exists in the southwestern part of the SCB; the Moho shallowers gradually from the west to east (ca. 62-36 km deep),the South-North seismic belt (SNSB) is very distinctive: the Moho depth is much shallower (< 50 km)to the east of the SNSB, whereas it is much deeper(>50 km)to the west of the SNSB, suggesting that the SNSB rather than the Longmen Shan tectonic belt is a main Moho transition belt; the topography and the top interface of the basement have the same undulation trend when the sedimentary thickness and the Moho depth have a mirror relationship; the low velocity zone developed in the Kangdian thrust and fold belt and Songpan-Garzê belt implied a soft, weak and thick crust there showing tectonic activity in these areas.