Paleocurrent indicator data collected in field work were used to study the early Cenozoic regional paleodrainage patterns in the Hoh Xil basin in northern Tibetan plateau. The paleocurrent directions of the Eocene Fenghuoshan Group obviously show that the flows were northward with a unidirectional dispersal pattern. This probably reflects the uplift of the Qiangtang terrain during the initial basin deposition period and indicates that the Tanggula Moutains occurred as topographic highlands at least in the Eocene. Paleoflows of the Oligocene Yaxicuo Group were dominantly oriented to the north and then flowed eastwards during its late deposition. This regional variability of paleodrainage patterns of the Yaxicuo Group is interpreted to record the dispersal style of sediments from transverse rivers to longitudinal river systems. It is inferred that the Oligocene uplift of the Kunlun Mountains obstructed by northward paleoflows and created longitudinal river systems parallel to the orogenic belts. The temporal and spatial changes of the paleodrainage patterns suggest that the northern boundary of the Tibetan plateau during the early Cenozoic was situated in the Hoh Xil area and its uplift has progressed northwards through time.