All the indium-rich deposits with indium contents in ores more than 100×10- 6 seems to be of cassiterite-sulfide deposits or Sn-bearing Pb-Zn deposits, e.g., in the Dachang Sn deposit in Guangxi, the Dulong Sn-Zn deposit in Yunnan, and the Meng'entaolegai Ag-Pb-Zn deposit in Inner Mongolia, the indium contents in ores range from 98×10-6 to 236×10-6 and show a good positive correlation with contents of zinc and tin, and their correlation coefficients are 0.8781 and 0.7430, respectively. The indium contents from such Sn-poor deposits as the Fozichong Pb-Zn deposit in Guangxi and the Huanren Pb-Zn deposit in Liaoning are generally lower than 10×10-6, i.e., whether tin is present or not in a deposit implies the enrichment extent of indium in ores. Whether the In enrichment itself in the ore -forming fluids or the ore-forming conditions has actually caused the enrichment/depletion of indium in the deposits? After studying the fluid inclusions in quartz crystallized at the main stage of mineralization of several In-rich and In-poor deposits in China, this paper analyzed the contents and studied the variation trend of In, Sn, Pb and Zn in the ore-forming fluids. The results show that the contents of lead and zinc in the ore-forming fluids of In-rich and -poor deposits are at the same level, and the lead contents range from 22×10-6 to 81×10-6 and zinc from 164×10-6 to 309×10-6, while the contents of indium and tin in the ore-forming fluids of In-rich deposits are far higher than those of In-poor deposits, with a difference of 1-2 orders of magnitude. Indium and tin contents in ore-forming fluid of In-rich deposits are 1.9×10-6-4.1×10-6 and 7×100-6-55×10-6, and there is a very good positive correlation between the two elements, with a correlation coefficient of 0.9552. Indium and tin contents in ore-forming fluid of In-poor deposits are 0.03×10-6-0.09×10-6 and 0.4×10-6--2.0×10-6, respectively, and there is no apparent correlation between them. This indicates, on one hand, that In-rich ore-forming fluids are the material basis for the formation of In-rich deposits, and, on the other hand, tin probably played a very important role in the transport and enrichment of indium.