During the Paleozoic, the Ordos area in the western North China Plate was located at the intersecting position of microplates and controlled by their interaction. The structural framework in the Ordos area, which underwent transformations in the Ordovician, the Carboniferous and the Permian respectively, was dominated by the alternation of uplift and depression. The transformations of structural framework are utilized as the clues to investigate the microplates＇ interacting type and its response in the Ordos area. According to the regional structural evolution, the Ordos area is simplified into an isopachous, isotropic and elastic shell model, and under proposed various boundary conditions, three series of numerical simulations corresponding to the three structural transformations are carried out to determine the detailed tectonic constraints. Numerical simulations reveal that the structure of the uplift and depression, which is similar to the actual pattern, develops only under one special boundary condition in each of the three series, indicating that the structural framework responds to the unique tectonic background. The simulation results show that in the Early Paleozoic, the L-shaped paleouplift formed nearby the southwestern corner of the Ordos area because the intensity of the compressions in the southern and western boundaries resulting from the ocean-continent collisions was similar. In the Late Paleozoic, it evolved into continent-continent （or arc-continent） interaction in the southern and northern boundaries; in the preliminary stage of the interaction, since the interface between the North China Plate and the plates on the south and north was narrow, the relative acting force was little and the regional western boundary immobile, and the structural framework in the basin was characterized by the N-S trending slender-waist-shaped uplift; as the interface between the plates expanded gradually, the extrusive force in the southern and northern boundaries of the North China Plate increased, resulting in the paleogeographic divisions showing E-W trending, and, the western boundary of the basin was extruded westward due to the intense compression inducing the local NE trending of paleogeographic division in the central area. The simulation results further reflect that the symmetry of the uplift-depression pattern is restricted by that of the boundary conditions, suggesting that the Paleozoic structural transformations of the Ordos area under boundary constraints accord with the universal physical symmetrical principle.