For understanding the possible deep-seated processes and geodynamic constrains on gold mineralization, comprehensive physicochemical and geochemical studies of gold mineralization have been undertaken within the paleo-lithosphere framework during the metallogenic epoch from the northwestern part of the Jiaodong Peninsula in this paper. A general image of the paleo-crust has been remained although it has been superimposed and reformed by post-metallogenic tectonic movements. The gold ore deposits occur usually in local uplifts and gradient belts featuring a turn from steep to gentle in granite-metamorphic contact zones, relative uplifts of gradient zones of the Curier isothermal interfaces, depressions of the Moho discontinuity and areas where depth contours are cut by isotherms perpendicularly. Gold mineralization and lithogenesis are characterized by high temperature, low pressure and high strength of thermal flux. The depth of mineralization ranges from 0.8 to 4.5 km. The depth of the top interface of the granitic complex in the metallogenic epoch is about 3 km. There is a low-velocity layer (LVL) at the bottom of the upper crust with a depth close to 19.5 km, which may be a detachment belt in the crust. The appearance of the LVL indicates the existence of paleo-hyperthermal fluid or relics of molten magma chambers, which reflects partial melting within the crust during the diagenetic and metallogenic epochs and the superposition effects of strike-slip shearing of the Tanlu fault zone. The subsidence of the Moho is probably attributed to the coupling process of the NW-SE continental collision between North China and the Yangtze Block and the strike-slip movement of the Tanlu fault accompanied with underplating of mantle magma in the northwestern part of the Jiaodong Peninsula. The underplating of mantle magma may result in partial melting and make granite magma transfer upwards. This is favorable for the migration of metallogenic materials from deep to shallow to be enriched to form deposits. Coupling interactions between the strike-slip of the Tanlu fault, the underplating of mantle magma, partial melting within the crust, and hyperthermal fluid, etc. may be the important factors controlling the gold mineralization and spatial structures in the metallogenic system.