The tectonic development of the Tarim block has experienced four stages, i. e. Earth's core accretion and block formation in the Precambrian, margin splitting, opening-closing and piecing up in the Early Palaeozoic, rift formation and plate unification in the Late Palaeozoic, and basin-mountain coupling and landform shaping in the Meso-Cenozoic, forming six ore-bearing formations and ore deposits of various genetic types in the Tianshan Mountains, Kunlun Mountains and Altun Mountains. In the peripheral areas of Tarim there are four giant intercontinental metallogenic belts passing through, the Central Tianshan and southwestern Tianshan belts in the former USSR and the Qinling-Qilian-Kunlun and Palaeo-Tethys belts in China. According to the macro-analysis on the nearly one thousand known deposits (occurrences) and geophysical-geochemical anomalies, and the information from reconnaissance in some areas, the region has very good prospects for mineral resources. Some of the metallogenic belts may well become the reserve bases for exploration of mineral resources in China.