Based on the complex structure and material resources,the complex geological setting of the Mesozoic-Cenozoic continent of China controlled four kinds of dynamic mechanisms of the continental tectonic-mineralization pattern, i.e. the dynamic mechanisms related to (1) underthrusting or collision, (2) activation of old tectonic belts or activity of new tectonic belts, (3) upwelling of mantle material and heat, and (4) interaction between the atmosphere, hydrosphere, biosphere and lithosphere. The four dynamic factors are related to and interact with each other; and the mantle-crust interaction leads to the regulhar time-space zonation of endogenetic deposits on a regional scale. The Meso-Cenozoic mineralization pattern in China can be outlined as the network tectono-metallogenic pattern constructed by NNE- and E-W-trending tectonics in eastern China, and multi-layer ring tectono-metallogenic pattern in the Qinghai-Tibet plateau and its northern and eastern neighbouring areas.