Taken as an example the Upper Permian reef section on the carbonate platformmargin at Ziyun, Guizhou, the paper discusses the missing time of a hiatus surface, an impor-tant problem in chemical sequence stratigraphy, with the concept of cosmic chemistry. Then thepaper proposes a series of new concepts for chemical sequence stratigraphy, including the con-densation surface, relative compaction factor and time missing factor. Finally a quantitativecurve of Late Permian relative sea-level change in the Ziyun area is presented with timecoordinates.