Three logarithmic linear equations between D_(Me)~(V/L) and [m_(NaCl)], and the relationship of D_(Me)~(V/L) versus F/Cl or K/Na mole ratios have been established by the experiments of the partitioning of Pb and Zn between granitic silicate melt and aqueous fluid. These results have been used to quantitatively study some essential problems, such as the possibility and degree of Pb-Zn mineralization in the system of granitic magma and hydrothermal fluid, and the influence of the relative contents of alkali and volatiles on the Pb-Zn mineralization in the same system. Some new points have been put forward in this paper.