Abstract: Based on new research results, we analyse the deep structures, kinematic characteristics and interior structure of the Shandong segment of Tan-Lu fault zone. The characteristics of Mesozoic-Cenozoic Tectonic evolution of the Shandong segment of Tan-Lu fault zone are also discussed. In the collision orogenesis period between Huanan crate and Huabei crate, the Shandong segment of Tan-Lu fault zone peformance acted as sinistral shearing strike-slip deformation; Its sinistral strike-slip movement from late Jurassic to early Eocene and the dextral strike-slip movement after early Eocene was controlled by the subduction of the old Pacific plate: The strike-slip movement of Tan-Lu fault zone was caused by the stress transferred from subducting plate boundary to it. The extensional activities of the Shandong segment of Tan-Lu fault zone and the basins beside it, was associated with the intracontinental rifting process caused by lithosphere delamination and upheaval of upper mantle.