Base on the study of orehosted dyke, mineralizing material sources, nature of mineralizing fluid and its geodynamic background, the digenetic and mineralization model of deposit is constructed. This study found that quartz fluid inclusions of the Tangjiaping Mo deposit in major mineralization stage present the characters as following: predominately the CO₂ inclusions and the mineralbearing multiphase inclusions, and a small amount of twophase gasliquid inclusions, the temperature of the main mineralization stage is between 260~419℃, the salinity of fluid inclusion presents typical bimodaldistribution pattern, mineralbearing multiphase inclusions with the salinity between 32.6%~48.54% (NaCl) is generally on behalf of waterbearing “Magma”. The mineralizing material was origin from the Morich granite magma which partial melted from Proterozoic Dabie gneissic complex. Mineralizing fluid is high temperature and high salinity of the initial magma water, and meteoric water added into the system during the middle and latter stages. In summary, the diagenetic and metallogenic model of the Tangjiaping Mo deposit presents: magma source original from remelting of the Dabie gneissic complexmagma intrusion and condensation stage under the extension systempotassic alternation and initial magmatic hydrothermal mineralization stagemeteoric water adding into the middle and latter mineralizing stages.