The Hongshishan chromitite deposits are situated to the north of the Beishan orogenic collage, in the southern part of the Central Asian Orogenic Belt. This study describes the mineral chemistry, Re-Os isotopes and platinum-group elements geochemistry of the Hongshishan chromitites for the purpose of constraining the origin, evolution and composition of their parental melts. The restricted ranges of Al2O3, Cr2O3 and Cr#-Mg# variation of chromite-cores and chromites fall within the field of the mid-ocean ridge and ophiolitic podiform chromite settings. The (187Os/188Os)i ratios of the chromitites are in the range of 0.12449–0.12745 (average 0.12637) and the γOs are from ?1.92 to ?0.06 (average ?0.83). In the Re-Os isotope diagrams, all the samples fall in the field of chromitites and show a residual peridotitic trend. The range of Os isotopic compositions and γOs values indicate that they overlap the depleted MORB mantle (DMM) as well as being close to global Os isotopic data and γOs of ophiolite chromitites. The characteristics of the PGE contents can be roughly subdivided into two groups: podiform chromitites and Ural-Alaskan type complexes. For the ferritchromite cores, the calculated Al2O3 concentrations of the parental melt are higher (average 16.65 wt%) in high-Cr than high-Al chromitite (average 16.17 wt%) and for the chromite, the calculated Al2O3 concentrations are even higher (average 16.48 wt%) in the high-Cr than the high-Al examples (average 15.38 wt%). In the (TiO2)melt vs. TiO2 diagrams, most high-Al melts fall in the MORB, while the high-Cr melts fall in the ARC field. The calculated FeO/MgO ratios for the parental melt show the closest resemblance to a MORB magma composition. The inferred parental melt composition for studied chromitites falls in the field of mid-ocean ridge basalt (MORB) magmas and far away from boninite. The calculated degrees of partial melting producing the chromitites are 16%?22% (average 19%), which is around the range of those of the MORB magmas. The chromitites are suggested to have been formed in a MORB setting. The chromites and ferritchromite cores are mostly scattered along the MORB and SSZ harzburgite–dunite fields. Ferritchromite rims and ferritchromites with high YFes formed as a result of alteration during serpentinization.