Cretaceous magmatism is widely distributed on both sides of the Bangong–Nujiang suture zone (BNSZ). These rocks record the subduction to closure history of the Bangong–Nujiang Tethys Ocean (BNO) and the collisional history between the Lhasa (LS) and Qiangtang (QT) terranes. The Xiabie Co granite in Nyima County, which located on the southern margin of the QT terrane, Tibet. In this study, whole-rock geochemistry; Rb-Sr, Sm-Nd, and Pb isotopes; and laser ablation inductively coupled mass spectrometry (LA-ICP-MS) zircon U-Pb ages and Lu-Hf isotopes of the Xiabie Co granite in the Nyima area have been studied to constrain its petrogenesis and tectonic setting. Our study can help explain the tectonic evolution of the BNSZ and crust-mantle interaction. Zircon U-Pb dating indicates that the granite was emplaced at ca. 120 Ma. The granite contains a small amount of hornblende and has high silicon (SiO2 = 73.97–78.03 wt%).