Abu Rusheid area lie in the south of the Eastern Desert of Egypt and comprises (1) ophiolitic mélange, consisting of ultramafic rocks and layered metagabbros in metasedimentary matrix (2) cataclastic group, consisting of protomylonites, mylonites, ultramylonites and silicified ultramylonites (3) monzogranites (4) pegmatite pockets, quartz veins and post-granite dykes. Focus on the monzogranites and the xenoliths of mylonite rocks from the geochemical and mineralogical points of view introduces a new view about the genesis of the related mineralization. Geochemically, the monzogranites have a metaluminous character and were crystallized under moderate water-vapor pressure around 3 kb and temperatures of 750–800°C. The monzogranites are altered along strike-slip faults exhibiting propylitic, with slightly sodic metasomatism and record high radioactive measurements. The average uranium and thorium (U and Th) contents in fresh monzogranites, mylonite xenolith and altered monzogranites are (7.3, 21.20), (40.36, 94.82), (60.34 and 347.88 ppm), respectively. These high radioactivities are attributed to the presence of kasolite, uranothorite, cerite, fluorite, zircon, apatite and columbite. The mylonite xenolith is higher in radioactivity than the surrounding fresh monzogranites, reflecting U and Th enrichment before emplacement of the monzogranites, then the latter were subjected to right lateral strike-slip faulting with producing hydrothermal solution rich in Th and U.