Coalbed methane (CBM) resources in No.15 coal seam of Taiyuan Formation account for 55% of the total CBM resources in southern Qinshui Basin (SQB), and have a great production potential. This study aims at investigating the CBM production in No.15 coal seam and its influence factors. Based on a series of laboratory experiments and latest exploration and development data from local coal mines and CBM companies, the spatial characteristics of gas production of No.15 coal seam were analyzed and then the influences of seven factors on the gas productivity of this coal seam were discussed, including coal thickness, burial depth, gas content, ratio of critical desorption pressure to original coal reservoir pressure (RCPOP), porosity, permeability, and hydrogeological condition. The influences of hydrological condition on CBM production were analyzed based on the discussions of four aspects: hydrogeochemistry, roof lithology and its distribution, hydrodynamic field of groundwater, and recharge rate of groundwater. Finally, a three-level analytic hierarchy process (AHP) evaluation model was proposed for predicting the CBM potentials of the No.15 coal seam in the SQB. The best prospective target area for CBM production of the No.15 coal seam is predicted to be in the districts of Panzhuang, Chengzhuang and south of Hudi.