In this study, we report U–Pb and Lu–Hf isotopic data for zircons from the Mesozoic sandstones of the Upper Yangtze area, which provide critical constraints on the provenance of these sediments and further shed light on the crustal evolution of the Upper Yangtze block. The results of isotopic chronology indicate the following: (1) The provenances of the study area are very complex, and the tectonic evolution process is relatively closed. (2) The provenances are mainly Archean–Proterozoic crystalline basement or recycled material; Paleoproterozoic crustal accretion in the western margin of the Yangtze block and Neoproterozoic magmatic activities related to subduction of the western margin of the Yangtze block; early Cambrian oceanic magmatic activity, which resulted from the intraplate extension of the northern margin of the Yangtze block; late Ordovician–early Silurian magmatic activity in the northern Yangtze block and Hercynian–Indochina uplift and erosion during the Hercynian movement. (3) The Yangtze crustal growth is episodic, and an increasing amount of ancient recycled material became part of the magmatic activity, as the zircon U–Pb ages are relatively young.