The Garzê–Yushu strike-slip fault in central Tibet is the locus of strong earthquakes (M > 7). The deformation and geometry of the co-seismic surface ruptures are reflected in the surface morphology of the fault and depend on the structure of the upper crust as well as the pre-existing tectonics. Therefore, the most recent co-seismic surface ruptures along the Garzê–Yushu fault zone (Dangjiang segment) reveal the surface deformation of the central Tibetan Plateau. Remote sensing images and field investigations suggest a 85 km long surface rupture zone (striking NW-NWW), less than 50 m wide, defined by discontinuous fault scarps, right-stepping en echelon tensional cracks and left-stepping mole tracks that point to a left-lateral strike-slip fault. The gullies that cross fault scarps record systematic left-lateral offsets of 1.8 m to 5.0 m owing to the most recent earthquake, with moment magnitude of about M 7.5, in the Dangjiang segment. Geological and geomorphological features suggest that the spatial distribution of the 1738 co-seismic surface rupture zone was controlled by the pre-existing active Garzê–Yushu fault zone (Dangjiang segment). We confirm that the Garzê–Yushu fault zone, a boundary between the Bayan Har Block to the north and the Qiangtang Block to the south, accommodates the eastward extrusion of the Tibetan Plateau and generates strong earthquakes that release the strain energy owing to the relative motion between the Bayan Har and Qiangtang Blocks.