The Yinkeng orefield in Yudu County, Jiangxi Province, SE China, is a zone of concentrated Au-Ag -Pb-Zn-Cu-Mn polymetallic ores. Based on summing up basic geology and ore geology of the orefield, the polymetallic deposits in the orefield have been divided into seven major substyles according to their occurring positions and control factors. The ore-forming fluid inclusion styles in the orefield include those of two-phase fluid, liquid CO2-bearing three-phase and daughter mineral-bearing multi-phase. The homogenization temperatures range from 382o to 122oC, falling into five clusters of 370o to 390o, 300o to 360o, 230o to 300o, 210o to 290o and 120o to 200o, and the clusters of 300o to 360o, 230o to 300o and 120o to 200o are three major mineralization stages, with fluid salinity peaks from 4.14% to 7.31%, 2.07% to 7.31% and 0.53% to 3.90%, respectively. The ore-forming fluids are mainly type of NaCl-H2O with medium to high density (0.74–1.02 g/cm3), or CO2-bearing NaCl-H2O with medium to low density (0.18–0.79 g/cm3). The fluid salinity and density both show a decline tendency with decreasing temperature. According to the measurement and calculation of H- and O-isotopic compositions in the quartz of the quartz-sulfide veins, δDV-SMOW of the ore-forming fluid is from ?84‰ to ?54‰, and δ18OV-SMOW of that is from 6.75‰ to 9.21‰, indicating a magmatic fluid. The δ34SV-CDT of sulfides in the ores fall into two groups, one is from ?4.4‰ to 2.2‰ with average of ?1.42‰, and the other from 18.8‰ to 21.6‰ with average of 19.8‰. The S-isotopic data shows one peak at ?4.4‰ to 2.2‰ (meaning ?1.42‰) suggesting a simple magmatic sulfur source. The ore Pb-isotopic ratios are 206Pb/204Pb from 17.817 to 17.983, 207Pb/204Pb from 15.470 to 15.620 and 208Pb/204Pb from 38.072 to 38.481, indicating characteristics of mantle-derived lead. The data show that the major ore deposits in the orefield have a magmatic-hydrothermal genesis and that the SHRIMP zircon age of the granodiorite porphyry, closely related to the mineralization, is 151.2±4.2 Ma (MSWD = 1.3), which can represent the formation ages of the ores and intrusion rocks. The study aids understanding of the ore-forming processes of the major metallic ore deposits in the orefield.