The upper reaches of the Yellow River in northeastern Tibetan Plateau are geohazards areas. The evolution of the Yellow River, chronology of some landslides, and spatiotemporal distribution characteristics of super large scale and giant landslides within the region are summarized using paleoclimate evidence, and the relationship between the intensive landslide period and climatic changes since the Last Glacial period is analyzed. It is concluded that (1) Super large scale and giant landslides are distributed widely within the region, particularly in the Qunke-Jianzha basin. (2) The chronological sequence of landslides is established by dating the slip zones of landslides and analyzing the relations between landslides and their overlying or underlying loess formations. Five landslide development periods are determined: 53–49 ka BP, 33–24 ka BP, 10–8 ka BP, 5–3.5 ka BP, and the present. (3) These correspond closely to warm and wet periods during the last 100,000 years, i.e., two weak paleosol development stages of Malan loess deposited during the last Glacial period in the Chinese loess Plateau, L1-4 and L1-2 that belong to the marine oxygen isotope stage 3, the last deglacial period, the Holocene Optimum, and the modern global warming period. (4) Landslide triggers may be closely linked to warm and wet periods related to rapid climatic transitions.