Early Miocene stratigraphy, major structural systems, magmatic emplacement, volcanic eruption, vegetation change and paleo-elevation were analyzed for the Tibetan Plateau after regional geological mapping at a scale of 1:250,000 and related researches, revealing much more information for tectonic evolution and topographic change of the high plateau caused by Indian-Asian continental collision. Lacustrine deposits of dolostone, dolomite limestone, limestone, marl, sandstone and conglomerate of weak deformation formed extensively in the central Tibetan Plateau, indicating that vast lake complexes as large as 100,000–120,000 km2 existed in the central plateau during Early Miocene. Sporopollen assemblages contained in the lacustrine strata indicate the disappearance of most tropical-subtropical broad-leaved trees since Early Miocene and the flourishing of dark needle-leaved trees during Early Miocene. Such vegetation changes adjusted for latitude and global climate variations demonstrate that the central Tibetan Plateau rose to ca. 4,000–4,500 m and the northeastern plateau uplifted to ca. 3,500–4,000 m before the Early Miocene. Intensive thrust and crustal thickening occurred in the areas surrounding central Tibetan Plateau in Early Miocene, formed Gangdise Thrust System (GTS) in the southern Lhasa block, Zedong-Renbu Thrust (ZRT) in the northern Himalaya block, Main Central Thrust (MCT) and Main Boundary Thrust (MBT) in the southern Himalaya block, and regional thrust systems in the Qaidam, Qilian, West Kunlun and Songpan-Ganzi blocks. Foreland basins formed in Early Miocene along major thrust systems, e.g. the Siwalik basin along MCT, Yalung-Zangbu Basin along GTS and ZRT, southwestern Tarim depression along West Kunlun Thrust, and large foreland basins along major thrust systems in the northeastern margin of the plateau. Intensive volcanic eruptions formed in the Qiangtang, Hoh-Xil and Kunlun blocks, porphyry granites and volcanic eruptions formed in the Nainqentanglha and Gangdise Mts., and leucogranites and granites formed in the Himalaya and Longmenshan Mts. in Early Miocene. The K2O weight percentages of Early Miocene magmatic rocks in the Gangdise and Himlayan Mts. are found to increase with distance from the MBT, indicating the genetic relationship between regional magmatism and subduction of Indian continental plate in Early Miocene.