The Ailaoshan-Red River (ASRR) shear zone is one of the major Southeast Asian tectonic discontinuities that have figured the present tectonic framework of the eastern Tibet. Several metamorphic massifs are distributed linearly along the shear zone, e.g. Xuelongshan, Diancangshan, Ailaoshan and Day Nui Con Voi from north to south. They bear a lot of lines of evidence for the tectonic evolution of the eastern Tibetan at different crustal levels in different tectonic stages. Controversy still exists on the deformation structures, microstructures and their relationship with metamorphisms along the ASRR. In this paper detailed microstructural and EBSD (Electron Backscattered Diffraction) fabric analysis of some highly sheared granitic rocks from different massifs along the ASRR are conducted. High temperature structures and microstructures are preserved in unsheared gneisses, in weakly sheared xenoliths or in some parts of the highly sheared rocks (mylonites). Several types of high temperature quartz c-axis fabrics show symmetrical patterns or transitions from symmetrical to asymmetrical patterns. The former are attributed to coaxial deformation during regional shortening in an early stage of the Indian-Eurasian tectonic interaction and the latter are related to the transitions from coaxial compression to noncoaxial shearing during the post-collisional ASRR left lateral shearing.