According to the oxidation intensity of ore-hosting sandstone, the interlayer oxidation zone of the Shihongtansandstone-type uranium deposit in the Turpan-Hami basin can be divided into 4 geochemical subzones, namely, intensely-oxidized, weakly-oxidized, redox and unoxidized primary subzones. The elemental geochemical characteristics of thefour subzones have been studied in detail, and the results show that U, together with other elements such as Re, Mo, Se, Sr,S, REE, Corganic etc., is enriched in the redox subzone. Re and U have similar geochemical properties in the reduction-oxidation process. The geochemical properties of Mo and Se are similar to those of U in the reduction condition, butdifferent from those of U in the oxidation condition. It is proposed that the ore-hosting layers can provide a curtain mountof uranium for uranium mineralization.