Continent-continent collision is the most important driving mechanism for the occurrence of various geological processes in the continental lithosphere. How to recognize and determine continent-continent collision, especially its four-dimensional temporal-spatial evolution, is a subject that geological communities have long been concerned about and studied. Continent-continent collision is mainly manifested by strong underthrusting (subduction) of the underlying block along an intracontinental subduction zone and continuous obduction (thrusting propagation) of the overlying block along the intracontinental subduction zone, the occurrence of a basin-range tectonic framework in a direction perpendicular to the subduction zone and the flexure and disruption of the Moho. On the basis of numerical modeling, the authors discuss in detail the couplings between various amounts and rates of displacement caused by basin subsidence, mountain uplift and Moho updoming and downflexure during obduction (thrusting propagation) and subduction and the migration pattern of basin centers. They are probably indications or criteria for judgment or determination of continent-continent collision.