This paper discusses the rational exploitation of main resources and prevention of geohazards in karst regions. There exist relationship chains between natural disasters in the earth, which include the chain between geological hazards and climatic hazards, the chain between geological hazards and biogenic hazards as well as the one between geological hazards. Irrational exploitation of all resources will inevitably cause hazards. Therefore it is very important to discuss the problem related to prevention of geohazards by rational exploitation of resources.