The Nanling region is an important nonferrous and rare metal metallogenic province in South China, in which most of the deposits are related to granitoids in genesis. It covers southern Hunan, southern Jiangxi, Guangxi, Guangdong and Fujian provinces, with a total area of about 550,000 km2. This metallogenic province is well known in the world for its rich tungsten and tin resources. In the past 40-odd years, a vast amount of mineral exploration activities and studies of the geology of mineral deposits have been carried out and great achievements obtained in the province. This paper is focused on a discussion about the deep tectonic processes in the orogenic belt during the Mesozoic and their contribution to the superaccumulation of metals. Tectonically, this metallogenic province is composed of three units: (1) the marginal continental orogenic belt in the Southeastern Coast fold system in the Yanshanian; (2) the intercontinental orogenic belt in the collision suture belt between the Yangtze and Cathay