The basalt terrain of the Neogene Huangguoshan and. Guiwu Formations of eastern Anhui on the east side of the Tancheng-Lujiang fault belt is one of a few Cenozoic basalt terrains in eastern China for which detailed geochemical study has not been conducted. This paper reports the abundances of major elements and more than 20 trace elements (including REE) of 22 samples and the Nd, Sr and Pb isotopic compositions of 11 samples from the eastern Anhui basalt terrain, thus more or less systematically revealing the geochemical characteristics of this continental basalt suite. The paper discusses the origin of the basalt suite and the character and process of its mantle source. The basalt suite was derived from a heterogeneous continental lithospheric mantle with end members characteristic of the EMI-type oceanic basalt mantle, which was affected by mantle metasomatism (or enrichment of trace elements) and was characterized by a multi-stage evolution under open conditions.