The principal of preferred plane analysis is a new research view and model of rock slope engineering geology. It advocates that the rock slope stability, boundary conditions and failure model are controlled by preferred planes. Therefore, the problem of slope stability evaluation can be converted into the search for preferred planes and determination of preferred separating bodies. The organic combination of the deterministic model and the indeterministic model can be realized by applying the systems engineering principle and the research model and method of reliability analysis in the quantitative evaluation and prediction of rock slope stability. Finally, the paper presents the case studies of slopes of the Yangtze Gorge Project and the Ma'anshan openpit mine.